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mAdb Feature Report
Clone IMAGE:50188     dbEST Insert Size: 1561
Library Source Soares infant brain 1NIB
3' Sequence H17943   UCSC's GenomeViewer      BLAST Results:   NT   NR   RefSeq   Genome
5' Sequence H17158   UCSC's GenomeViewer      BLAST Results:   NT   NR   RefSeq   Genome

mAdb Annotation SourceGenBank Accession H17158 Maps to UniGene Cluster
mAdb Mapping
Mapped   Str   Chr  Chr:Start-Stop BP    Cytoband    Genome Assembly 
CytoGenetic Map4p16.3
Entrez GeneID 6047
Gene SymbolRNF4  GeneCards  
UniGene ClusterTP  Hs.66394    CGAP's Gene
RefSeqs in Cluster NM_001185009 NM_001185010 NM_002938
UG TitleRing finger protein 4
Gene Summary
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]
REACTOME Pathways   Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
Homology Directed Repair
Immune System
Processing of DNA double-strand break ends
Gene Ontology
GO TM Annotations   Evidence   Source    Pub 
androgen receptor binding   NAS   GOA   PM
DNA binding   ISS   GOA  
identical protein binding   IPI   GOA   PM
nuclear receptor transcription coactivator activity   TAS   GOA   PM
nucleosome binding   ISS   GOA  
protein binding   IPI   GOA   PM
SUMO polymer binding   ISS   GOA  
transcription coactivator activity   NAS   GOA   PM
transcription factor binding   IBA   GOA   PM
ubiquitin-protein transferase activity   ISS   GOA  
zinc ion binding   TAS   GOA   PM
androgen receptor signaling pathway   NAS   GOA   PM
positive regulation of transcription by RNA polymerase II   IBA   GOA   PM
positive regulation of transcription by RNA polymerase II   IDA   GOA   PM
positive regulation of transcription, DNA-templated   ISS   GOA  
proteasome-mediated ubiquitin-dependent protein catabolic process   IMP   GOA   PM
protein autoubiquitination   ISS   GOA  
protein K11-linked ubiquitination   ISS   GOA  
protein K48-linked ubiquitination   ISS   GOA  
protein K6-linked ubiquitination   ISS   GOA  
protein K63-linked ubiquitination   ISS   GOA  
regulation of kinetochore assembly   IMP   GOA   PM
regulation of spindle assembly   IMP   GOA   PM
response to arsenic-containing substance   IDA   GOA   PM
cytoplasm   IDA   GOA   PM
nucleoplasm   TAS   GOA  
nucleus   IDA   GOA   PM
PML body   IBA   GOA   PM
PML body   IDA   GOA   PM

NIH BioInformatics support provided by BIMAS/CBEL/OIR/CIT.
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